KMT2B Is Selectively Required for Neuronal Transdifferentiation, and Its Loss Exposes Dystonia Candidate Genes

KMT2B Is Selectively Required for Neuronal Transdifferentiation, and Its Loss Exposes Dystonia Candidate Genes

Summary: Transdifferentiation of fibroblasts into induced neuronal cells (iNs) by the neuron-specific transcription factors Brn2, Myt1l, and Ascl1 is a paradigmatic example of inter-lineage conversion across epigenetically distant cells. Despite tremendous progress regarding the transcriptional hier...

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Bibliographic Details
Main Authors: Giulia Barbagiovanni, Pierre-Luc Germain, Michael Zech, Sina Atashpaz, Pietro Lo Riso, Agnieszka D’Antonio-Chronowska, Erika Tenderini, Massimiliano Caiazzo, Sylvia Boesch, Robert Jech, Bernhard Haslinger, Vania Broccoli, Adrian Francis Stewart, Juliane Winkelmann, Giuseppe Testa
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718315274

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http://www.sciencedirect.com/science/article/pii/S2211124718315274

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