IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides

IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides

<p>Abstract</p> <p>The airway epithelium forms a barrier against infection but also produces antimicrobial peptides (AMPs) and other inflammatory mediators to activate the immune system. It has been shown that in allergic disorders, Th2 cytokines may hamper the antimicrobial activi...

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Bibliographic Details
Main Authors: Prins Frans A, Verhoosel Renate M, van Sterkenburg Marianne AJA, Schrumpf Jasmijn A, Ninaber Dennis K, Zuyderduyn Suzanne, van Wetering Sandra, Rabe Klaus F, Hiemstra Pieter S
Format: Article
Language:English
Published: BMC 2011-05-01
Series:Respiratory Research
Subjects:
human
lung
cell differentiation
allergy
inflammation
Online Access:http://respiratory-research.com/content/12/1/59

Internet

http://respiratory-research.com/content/12/1/59

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