Senescence Marker Protein-30 (SMP30) Deficiency Impairs Myocardium-Induced Dilation of Coronary Arterioles Associated with Reactive Oxygen Species

Senescence Marker Protein-30 (SMP30) Deficiency Impairs Myocardium-Induced Dilation of Coronary Arterioles Associated with Reactive Oxygen Species

Senescence marker protein-30 (SMP30) decreases with aging. Mice with SMP30 deficiency, a model of aging, have a short lifespan with increased oxidant stress. To elucidate SMP30’s effect on coronary circulation derived from myocytes, we measured the changes in the diameter of isolated coronary arteri...

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Bibliographic Details
Main Authors: Hiroyuki Mizukami, Shu-ichi Saitoh, Hirofumi Machii, Shinya Yamada, Yasuto Hoshino, Tomofumi Misaka, Akihito Ishigami, Yasuchika Takeishi
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:International Journal of Molecular Sciences
Subjects:
coronary circulation
oxidant stress
SMP30
cardiac myocyte
coronary arterioles
vasomotor tone
Online Access:http://www.mdpi.com/1422-0067/14/5/9408

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http://www.mdpi.com/1422-0067/14/5/9408

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