Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Abstract Background Spinal cord injury (SCI) is a devastating condition mainly deriving from a traumatic damage of the spinal cord (SC). Immune cells and endogenous SC-neural stem cells (SC-NSCs) play a critical role in wound healing processes, although both are ineffective to completely restore tis...

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Bibliographic Details
Main Authors: Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D’Adamo, Luca Muzio, Gianvito Martino
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Neuroinflammation
Subjects:
Spinal cord injury
Endogenous neural stem cells
Neurotrophic factors
Inflammation
Online Access:http://link.springer.com/article/10.1186/s12974-018-1085-9

Internet

http://link.springer.com/article/10.1186/s12974-018-1085-9

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