Fibrinogen as a Pleiotropic Protein Causing Human Diseases: The Mutational Burden of Aα, Bβ, and γ Chains

Fibrinogen as a Pleiotropic Protein Causing Human Diseases: The Mutational Burden of Aα, Bβ, and γ Chains

Fibrinogen is a highly pleiotropic protein that is involved in the final step of the coagulation cascade, wound healing, inflammation, and angiogenesis. Heterozygous mutations in Aα, Bβ, or γ fibrinogen-chain genes (FGA, FGB, FGG) have been described as being responsible for fibrinogen deficiencies...

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Bibliographic Details
Main Authors: Elvezia Maria Paraboschi, Stefano Duga, Rosanna Asselta
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:International Journal of Molecular Sciences
Subjects:
fibrinogen
afibrinogenemia
hypofibrinogenemia
dysfibrinogenemia
hepatic fibrinogen storage disease
hereditary renal amyloidosis
FGA
FGB
FGG
exome-based epidemiology
Online Access:https://www.mdpi.com/1422-0067/18/12/2711

Internet

https://www.mdpi.com/1422-0067/18/12/2711

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