Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes.

Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes.

It has long been thought that iminosugar antiviral activity is a function of inhibition of endoplasmic reticulum-resident α-glucosidases, and on this basis, many iminosugars have been investigated as therapeutic agents for treatment of infection by a diverse spectrum of viruses, including dengue vir...

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Bibliographic Details
Main Authors: Andrew C Sayce, Dominic S Alonzi, Sarah S Killingbeck, Beatrice E Tyrrell, Michelle L Hill, Alessandro T Caputo, Ren Iwaki, Kyoko Kinami, Daisuke Ide, J L Kiappes, P Robert Beatty, Atsushi Kato, Eva Harris, Raymond A Dwek, Joanna L Miller, Nicole Zitzmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-03-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4790851?pdf=render

Internet

http://europepmc.org/articles/PMC4790851?pdf=render

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