IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes

Intraepithelial lymphocytes (IEL) respond to IL-15 complexed with IL-15Ra but how this intrinsically affects IEL is unclear. Here the authors use proteomics analyses of the main mouse IEL subsets and identify PIM kinases as essential for IEL proliferation, metabolism and effector function downstream...

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Bibliographic Details
Main Authors: Olivia J. James, Maud Vandereyken, Julia M. Marchingo, Francois Singh, Susan E. Bray, Jamie Wilson, Andrew G. Love, Mahima Swamy
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24473-2