Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications

Advances in nanotechnology and nanomaterials have enabled the development of functional biomaterials with surface properties that reduce the rate of the device rejection in injectable and implantable biomaterials. In addition, the surface of biomaterials can be functionalized with macromolecules for...

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Main Authors: Madeline Small, Addison Faglie, Alexandra J. Craig, Martha Pieper, Vivian E. Fernand Narcisse, Pierre F. Neuenschwander, Shih-Feng Chou
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Micromachines
Subjects:
Online Access:http://www.mdpi.com/2072-666X/9/5/243
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spelling doaj-b946d947420749f0b7549d85dd4b615a2020-11-24T22:28:20ZengMDPI AGMicromachines2072-666X2018-05-019524310.3390/mi9050243mi9050243Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical ApplicationsMadeline Small0Addison Faglie1Alexandra J. Craig2Martha Pieper3Vivian E. Fernand Narcisse4Pierre F. Neuenschwander5Shih-Feng Chou6Department of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, 3900 University Blvd., Tyler, TX 75799, USADepartment of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, 3900 University Blvd., Tyler, TX 75799, USADepartment of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, 3900 University Blvd., Tyler, TX 75799, USADepartment of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, 3900 University Blvd., Tyler, TX 75799, USADepartment of Chemistry and Physics, School of Arts and Sciences, LeTourneau University, Longview, TX 75607, USADepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USADepartment of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, 3900 University Blvd., Tyler, TX 75799, USAAdvances in nanotechnology and nanomaterials have enabled the development of functional biomaterials with surface properties that reduce the rate of the device rejection in injectable and implantable biomaterials. In addition, the surface of biomaterials can be functionalized with macromolecules for stimuli-responsive purposes to improve the efficacy and effectiveness in drug release applications. Furthermore, macromolecule-grafted surfaces exhibit a hierarchical nanostructure that mimics nanotextured surfaces for the promotion of cellular responses in tissue engineering. Owing to these unique properties, this review focuses on the grafting of macromolecules on the surfaces of various biomaterials (e.g., films, fibers, hydrogels, and etc.) to create nanostructure-enabled and macromolecule-grafted surfaces for biomedical applications, such as thrombosis prevention and wound healing. The macromolecule-modified surfaces can be treated as a functional device that either passively inhibits adverse effects from injectable and implantable devices or actively delivers biological agents that are locally based on proper stimulation. In this review, several methods are discussed to enable the surface of biomaterials to be used for further grafting of macromolecules. In addition, we review surface-modified films (coatings) and fibers with respect to several biomedical applications. Our review provides a scientific update on the current achievements and future trends of nanostructure-enabled and macromolecule-grafted surfaces in biomedical applications.http://www.mdpi.com/2072-666X/9/5/243macromoleculesgraftingsurfacesthrombosiswound healing
collection DOAJ
language English
format Article
sources DOAJ
author Madeline Small
Addison Faglie
Alexandra J. Craig
Martha Pieper
Vivian E. Fernand Narcisse
Pierre F. Neuenschwander
Shih-Feng Chou
spellingShingle Madeline Small
Addison Faglie
Alexandra J. Craig
Martha Pieper
Vivian E. Fernand Narcisse
Pierre F. Neuenschwander
Shih-Feng Chou
Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications
Micromachines
macromolecules
grafting
surfaces
thrombosis
wound healing
author_facet Madeline Small
Addison Faglie
Alexandra J. Craig
Martha Pieper
Vivian E. Fernand Narcisse
Pierre F. Neuenschwander
Shih-Feng Chou
author_sort Madeline Small
title Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications
title_short Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications
title_full Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications
title_fullStr Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications
title_full_unstemmed Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications
title_sort nanostructure-enabled and macromolecule-grafted surfaces for biomedical applications
publisher MDPI AG
series Micromachines
issn 2072-666X
publishDate 2018-05-01
description Advances in nanotechnology and nanomaterials have enabled the development of functional biomaterials with surface properties that reduce the rate of the device rejection in injectable and implantable biomaterials. In addition, the surface of biomaterials can be functionalized with macromolecules for stimuli-responsive purposes to improve the efficacy and effectiveness in drug release applications. Furthermore, macromolecule-grafted surfaces exhibit a hierarchical nanostructure that mimics nanotextured surfaces for the promotion of cellular responses in tissue engineering. Owing to these unique properties, this review focuses on the grafting of macromolecules on the surfaces of various biomaterials (e.g., films, fibers, hydrogels, and etc.) to create nanostructure-enabled and macromolecule-grafted surfaces for biomedical applications, such as thrombosis prevention and wound healing. The macromolecule-modified surfaces can be treated as a functional device that either passively inhibits adverse effects from injectable and implantable devices or actively delivers biological agents that are locally based on proper stimulation. In this review, several methods are discussed to enable the surface of biomaterials to be used for further grafting of macromolecules. In addition, we review surface-modified films (coatings) and fibers with respect to several biomedical applications. Our review provides a scientific update on the current achievements and future trends of nanostructure-enabled and macromolecule-grafted surfaces in biomedical applications.
topic macromolecules
grafting
surfaces
thrombosis
wound healing
url http://www.mdpi.com/2072-666X/9/5/243
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