Monomethyl auristatin E Exhibits Potent Cytotoxic Activity against Human Cancer Cell Lines SKBR3 and HEK293

Monomethyl auristatin E Exhibits Potent Cytotoxic Activity against Human Cancer Cell Lines SKBR3 and HEK293

<h2>Background: Monomethyl auristatin E (MMAE) is a synthetic analog of dolastatin 10, a compound originally isolated from the marine mollusk. MMAE, as a highly potent microtubule inhibitor, exerts its potent cytotoxic effect by inhibiting microtubule assembly, tubulin-dependent GTP hydrolysis...

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Bibliographic Details
Main Authors: Meghdad Abdollahpour-Alitappeh, Sepand Razavi-vakhshourpour, Majid Lotfinia, Saeed Jahandideh, Hamid Najminejad, Saeed Balalaie, Reza Moazzami, Elnaz Shams, Mahdi Habibi-Anbouhi, Mohsen Abolhassani
Format: Article
Language:English
Published: Shahid Beheshti University of Medical Sciences 2017-10-01
Series:Novelty in Biomedicine
Subjects:
Monomethyl auristatin E
cytotoxicity
Antibody-drug conjugate
SKBR3
HEK293
Online Access:http://journals.sbmu.ac.ir/nbm/article/view/15221

Internet

http://journals.sbmu.ac.ir/nbm/article/view/15221

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