Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology

Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology

The activation of nuclear factor κB (NF-κB) contributes to muscle degeneration that results from dystrophin deficiency in human Duchenne muscular dystrophy (DMD) and in the mdx mouse. In dystrophic muscle, NF-κB participates in inflammation and failure of muscle regeneration. Peptides containing the...

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Bibliographic Details
Main Authors: Daniel P. Reay, Michele Yang, Jon F. Watchko, Molly Daood, Terrence L. O'Day, Khaleel K. Rehman, Denis C. Guttridge, Paul D. Robbins, Paula R. Clemens
Format: Article
Language:English
Published: Elsevier 2011-09-01
Series:Neurobiology of Disease
Subjects:
Duchenne muscular dystrophy
mdx mouse
Histopathology
Muscle necrosis
Muscle regeneration
Specific force
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111001641

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http://www.sciencedirect.com/science/article/pii/S0969996111001641

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