Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis

Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis

Abstract Bioactive lipids contribute to the pathophysiology of multiple sclerosis. Here, we show that lysophosphatidic acids (LPAs) are dysregulated in multiple sclerosis (MS) and are functionally relevant in this disease. LPAs and autotaxin, the major enzyme producing extracellular LPAs, were analy...

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Bibliographic Details
Main Authors: K. Schmitz, R. Brunkhorst, N. de Bruin, C. A. Mayer, A. Häussler, N. Ferreiros, S. Schiffmann, M. J. Parnham, S. Tunaru, J. Chun, S. Offermanns, C. Foerch, K. Scholich, J. Vogt, S. Wicker, J. Lötsch, G. Geisslinger, I. Tegeder
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Acta Neuropathologica Communications
Subjects:
Lysophosphatidic acids
Multiple sclerosis
Autoimmune encephalomyelitis
Lpar2
Neuroinflammation
Spinal cord
Online Access:http://link.springer.com/article/10.1186/s40478-017-0446-4

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http://link.springer.com/article/10.1186/s40478-017-0446-4

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