CRISPR/Cas9-mediated simultaneous knockout of Dmrt1 and Dmrt3 does not recapitulate the 46,XY gonadal dysgenesis observed in 9p24.3 deletion patients

CRISPR/Cas9-mediated simultaneous knockout of Dmrt1 and Dmrt3 does not recapitulate the 46,XY gonadal dysgenesis observed in 9p24.3 deletion patients

DM domain transcription factors play important roles in sexual development in a wide variety of species from invertebrate to humans. Among seven mammalian family members of DM domain transcription factors, DMRT1 has been studied in mouse and human for its conserved role in male gonadal identity. Chr...

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Bibliographic Details
Main Authors: Masafumi Inui, Moe Tamano, Tomoko Kato, Shuji Takada
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Dmrt1
Dmrt3
CRISPR/Cas9
Gonadal dysgenesis
Sexual development
Testis
Online Access:http://www.sciencedirect.com/science/article/pii/S240558081630173X

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http://www.sciencedirect.com/science/article/pii/S240558081630173X

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