Loss of Function in Dopamine D3 Receptor Attenuates Left Ventricular Cardiac Fibroblast Migration and Proliferation in vitro

Loss of Function in Dopamine D3 Receptor Attenuates Left Ventricular Cardiac Fibroblast Migration and Proliferation in vitro

Evidence suggests the existence of an intracardiac dopaminergic system that plays a pivotal role in regulating cardiac function and fibrosis through G-protein coupled receptors, particularly mediated by dopamine receptor 3 (D3R). However, the expression of dopamine receptors in cardiac tissue and th...

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Bibliographic Details
Main Authors: Andrew Kisling, Shannon Byrne, Rohan U. Parekh, Deepthy Melit-Thomas, Lisandra E. de Castro Brás, Robert M. Lust, Stefan Clemens, Srinivas Sriramula, Laxmansa C. Katwa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cardiac fibroblasts
dopamine D3 receptor
dopamine D1 receptor
proliferation
migration
scratch injury
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.732282/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.732282/full

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