Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6

Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6

The strength of long bones is determined by coalescence of trabeculae during corticalization. Here the authors show that this process is regulated by SOCS3 via a mechanism dependent on IL-6 and expression of sex hormones.

Bibliographic Details
Main Authors: Dae-Chul Cho, Holly J. Brennan, Rachelle W. Johnson, Ingrid J. Poulton, Jonathan H. Gooi, Brett A. Tonkin, Narelle E. McGregor, Emma C. Walker, David J. Handelsman, T. J. Martin, Natalie A. Sims
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00920-x

Internet

https://doi.org/10.1038/s41467-017-00920-x

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