Deficiency of Gankyrin in the small intestine is associated with augmented colitis accompanied by altered bacterial composition of intestinal microbiota

Deficiency of Gankyrin in the small intestine is associated with augmented colitis accompanied by altered bacterial composition of intestinal microbiota

Abstract Background Gankyrin (GK) is an oncoprotein which regulates inflammatory responses and its inhibition is considered as a possible anti-inflammatory therapy for inflammatory bowel disease (IBD). Methods In this study, we investigated the role of GK in epithelial cells using mice with intestin...

Full description

Bibliographic Details
Main Authors: Toshiharu Sakurai, Hiroki Nishiyama, Tomoyuki Nagai, Susumu Goto, Hiroyuki Ogata, Masatoshi Kudo
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Gastroenterology
Subjects:
Inflammatory bowel disease
Gankyrin
Microbiota
Helicobacter japonicum
Bilophila
Online Access:https://doi.org/10.1186/s12876-019-1156-0

Internet

https://doi.org/10.1186/s12876-019-1156-0

Similar Items