Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex

Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex

We hypothesized that an interplay between aryl hydrocarbon receptor (AhR) and cysteine-related thiolome at the kidney cortex underlies the mechanisms of (mal)adaptation to chronic intermittent hypoxia (CIH), promoting arterial hypertension (HTN). Using a rat model of CIH-HTN, we investigated the imp...

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Bibliographic Details
Main Authors: Maria João Correia, António B. Pimpão, Filipa Lopes-Coelho, Catarina O. Sequeira, Nuno R. Coelho, Clara Gonçalves-Dias, Robert Barouki, Xavier Coumoul, Jacinta Serpa, Judit Morello, Emília C. Monteiro, Sofia A. Pereira
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Antioxidants
Subjects:
thiols
non-radical oxidative species
obstructive sleep apnea
arterial hypertension
CYP1A1
xCT
Online Access:https://www.mdpi.com/2076-3921/10/9/1484

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https://www.mdpi.com/2076-3921/10/9/1484

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