Nano-hydroxyapatite accelerates vascular calcification via lysosome impairment and autophagy dysfunction in smooth muscle cells

Nano-hydroxyapatite accelerates vascular calcification via lysosome impairment and autophagy dysfunction in smooth muscle cells

Vascular calcification (VC) is a common characteristic of aging, diabetes, chronic renal failure, and atherosclerosis. The basic component of VC is hydroxyapatite (HAp). Nano-sized HAp (nHAp) has been identified to play an essential role in the development of pathological calcification of vasculatur...

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Bibliographic Details
Main Authors: Qi Liu, Yi Luo, Yun Zhao, Pingping Xiang, Jinyun Zhu, Wangwei Jing, Wenjing Jin, Mingyao Chen, Ruikang Tang, Hong Yu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-02-01
Series:Bioactive Materials
Subjects:
Nano-hydroxyapatite
Vascular calcification
Autophagy
Lysosome
Exosome
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21002875

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http://www.sciencedirect.com/science/article/pii/S2452199X21002875

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