Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages

Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages

Macrophages perform critical functions in both innate immunity and cholesterol metabolism. Here, we report that activation of Toll-like receptor 4 (TLR4) in macrophages causes lanosterol, the first sterol intermediate in the cholesterol biosynthetic pathway, to accumulate. This effect is due to type...

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Bibliographic Details
Main Authors: Elisa Araldi, Marta Fernández-Fuertes, Alberto Canfrán-Duque, Wenwen Tang, Gary W. Cline, Julio Madrigal-Matute, Jordan S. Pober, Miguel A. Lasunción, Dianqing Wu, Carlos Fernández-Hernando, Yajaira Suárez
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
lanosterol
innate immunity
TLR4
macrophage
Cyp51A1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717308100

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717308100

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