Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate[S]

Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate[S]

Sphingosine kinase 1 (SK1) produces sphingosine-1-phosphate (S1P), a potent signaling lipid. The subcellular localization of SK1 can dictate its signaling function. Here, we use artificial targeting of SK1 to either the plasma membrane (PM) or the endoplasmic reticulum (ER) to test the effects of co...

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Bibliographic Details
Main Authors: Deanna L. Siow, Charles D. Anderson, Evgeny V. Berdyshev, Anastasia Skobeleva, Stuart M. Pitson, Binks W. Wattenberg
Format: Article
Language:English
Published: Elsevier 2010-09-01
Series:Journal of Lipid Research
Subjects:
sphingolipid metabolism
lipid kinase
phosphorylated sphingolipid
sphingosine-1-phosphate lyase
sphingosine
ceramide
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520422850

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http://www.sciencedirect.com/science/article/pii/S0022227520422850

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