The antibody targeting the E314 peptide of human Kv1.3 pore region serves as a novel, potent and specific channel blocker.

The antibody targeting the E314 peptide of human Kv1.3 pore region serves as a novel, potent and specific channel blocker.

Selective blockade of Kv1.3 channels in effector memory T (T(EM)) cells was validated to ameliorate autoimmune or autoimmune-associated diseases. We generated the antibody directed against one peptide of human Kv1.3 (hKv1.3) extracellular loop as a novel and possible Kv1.3 blocker. One peptide of hK...

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Bibliographic Details
Main Authors: Xiao-Fang Yang, Yong Yang, Yi-Tian Lian, Zhao-Hui Wang, Xiao-Wei Li, Long-Xian Cheng, Jin-Ping Liu, Yan-Fu Wang, Xiang Gao, Yu-Hua Liao, Min Wang, Qiu-Tang Zeng, Kun Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3338681?pdf=render

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http://europepmc.org/articles/PMC3338681?pdf=render

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