Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy

Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy

Emerging reports show that metabolic pathways can be targeted to enhance T cell-mediated immunity to tumors. Yet, tumors consume key metabolites in the host to survive, thus robbing T cells of these nutrients to function and thrive. T cells are often deprived of basic building blocks for energy in t...

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Bibliographic Details
Main Authors: Guillermo O. Rangel Rivera, Hannah M. Knochelmann, Connor J. Dwyer, Aubrey S. Smith, Megan M. Wyatt, Amalia M. Rivera-Reyes, Jessica E. Thaxton, Chrystal M. Paulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
T cell metabolism
tumor microenvironment
adoptive T cell transfer
immune checkpoint therapy
tumor metabolism
tumor infiltrating lymphocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.645242/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.645242/full

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