Pinin protects astrocytes from cell death after acute ischemic stroke via maintenance of mitochondrial anti-apoptotic and bioenergetics functions

Pinin protects astrocytes from cell death after acute ischemic stroke via maintenance of mitochondrial anti-apoptotic and bioenergetics functions

Abstract Background Stroke is the second most common cause of deaths worldwide. After an ischemic stroke, the proliferated reactive astrocytes in the peri-infarct areas play a beneficial role in neuronal survival. As such, astrocytes have gradually become a target for neuroprotection in stroke. The...

Full description

Bibliographic Details
Main Authors: Sujira Mukda, Ching-Yi Tsai, Steve Leu, Jenq-Lin Yang, Samuel H. H. Chan
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Biomedical Science
Subjects:
Middle cerebral artery occlusion
Oxygen-glucose deprivation
Primary cultured astrocytes
Cytotoxic edema
Peri-infarct area
Online Access:http://link.springer.com/article/10.1186/s12929-019-0538-5

Internet

http://link.springer.com/article/10.1186/s12929-019-0538-5

Similar Items