RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory

RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory

RNASET2 deficiency in humans is associated with infant cystic leukoencephalopathy, which causes psychomotor impairment, spasticity and epilepsy. A zebrafish mutant model suggests that loss of RNASET2 function leads to neurodegeneration due to the accumulation of non-degraded RNA in the lysosomes. Th...

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Bibliographic Details
Main Authors: Kerstin W. Sinkevicius, Thomas R. Morrison, Praveen Kulkarni, Martha K. Caffrey Cagliostro, Sade Iriah, Samantha Malmberg, Julia Sabrick, Jennifer A. Honeycutt, Kim L. Askew, Malav Trivedi, Craig F. Ferris
Format: Article
Language:English
Published: The Company of Biologists 2018-06-01
Series:Disease Models & Mechanisms
Subjects:
Diffusion-weighted imaging
Magnetic resonance imaging
CRISPR/Cas9
Lysosomal storage disease
Object recognition
Glial fibrillary acidic protein
Online Access:http://dmm.biologists.org/content/11/6/dmm032631

Internet

http://dmm.biologists.org/content/11/6/dmm032631

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