RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory
RNASET2 deficiency in humans is associated with infant cystic leukoencephalopathy, which causes psychomotor impairment, spasticity and epilepsy. A zebrafish mutant model suggests that loss of RNASET2 function leads to neurodegeneration due to the accumulation of non-degraded RNA in the lysosomes. Th...
Main Authors: | Kerstin W. Sinkevicius, Thomas R. Morrison, Praveen Kulkarni, Martha K. Caffrey Cagliostro, Sade Iriah, Samantha Malmberg, Julia Sabrick, Jennifer A. Honeycutt, Kim L. Askew, Malav Trivedi, Craig F. Ferris |
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Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2018-06-01
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Series: | Disease Models & Mechanisms |
Subjects: | |
Online Access: | http://dmm.biologists.org/content/11/6/dmm032631 |
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