The Lethality of [Pazopanib + HDAC Inhibitors] Is Enhanced by Neratinib

Sarcomas are a diverse set of malignancies. For soft tissue sarcomas, the kinase and chaperone inhibitor pazopanib is a standard of care therapeutic. Previously, we demonstrated that HDAC inhibitors enhanced pazopanib lethality against sarcoma and other tumor cell types in vitro and in vivo. The pre...

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Bibliographic Details
Main Authors: Laurence Booth, Jane L. Roberts, Andrew Poklepovic, Paul Dent
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00650/full