Droplet digital PCR for the quantification of Alu methylation status in hematological malignancies

Droplet digital PCR for the quantification of Alu methylation status in hematological malignancies

Abstract Background Alu repeats, belonging to the Short Interspersed Repetitive Elements (SINEs) class, contain about 25% of CpG sites in the human genome. Alu sequences lie in gene-rich regions, so their methylation is an important transcriptional regulation mechanism. Aberrant Alu methylation has...

Full description

Bibliographic Details
Main Authors: Paola Orsini, Luciana Impera, Elisa Parciante, Cosimo Cumbo, Crescenzio F. Minervini, Angela Minervini, Antonella Zagaria, Luisa Anelli, Nicoletta Coccaro, Paola Casieri, Giuseppina Tota, Claudia Brunetti, Alessandra Ricco, Paola Carluccio, Giorgina Specchia, Francesco Albano
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Diagnostic Pathology
Subjects:
Alu repeats
DNA methylation
ddPCR
Hematological malignancies
Hypomethylating agents
Online Access:http://link.springer.com/article/10.1186/s13000-018-0777-x

Internet

http://link.springer.com/article/10.1186/s13000-018-0777-x

Similar Items