Opportunistic Pathogen Porphyromonas gingivalis Modulates Danger Signal ATP-Mediated Antibacterial NOX2 Pathways in Primary Epithelial Cells

Opportunistic Pathogen Porphyromonas gingivalis Modulates Danger Signal ATP-Mediated Antibacterial NOX2 Pathways in Primary Epithelial Cells

Porphyromonas gingivalis, a major opportunistic pathogen in the etiology of chronic periodontitis, successfully survives in human gingival epithelial cells (GECs). P. gingivalis abrogates the effects of a host danger molecule, extracellular ATP (eATP)/P2X7 signaling, such as the generation of reacti...

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Bibliographic Details
Main Authors: JoAnn S. Roberts, Kalina R. Atanasova, Jungnam Lee, Gill Diamond, Jeff Deguzman, Chul Hee Choi, Özlem Yilmaz
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
opportunistic oral bacteria
persistence
ROS
NADPH oxidase
myeloperoxidase
glutathione
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00291/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00291/full

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