Survival of glucose phosphate isomerase null somatic cells and germ cells in adult mouse chimaeras

The mouse Gpi1 gene encodes the glycolytic enzyme glucose phosphate isomerase. Homozygous Gpi1−/− null mouse embryos die but a previous study showed that some homozygous Gpi1−/− null cells survived when combined with wild-type cells in fetal chimaeras. One adult female Gpi1−/−↔Gpi1c/c chimaera with...

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Bibliographic Details
Main Authors: Margaret A. Keighren, Jean H. Flockhart, John D. West
Format: Article
Language:English
Published: The Company of Biologists 2016-05-01
Series:Biology Open
Subjects:
Online Access:http://bio.biologists.org/content/5/5/596