Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein

Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein

The activation induced cytidine deaminase (AID) protein is known to initiate somatic hypermutation, gene conversion or switch recombination by cytidine deamination within the immunoglobulin loci. Using chromosomally integrated fluorescence reporter transgenes, we demonstrate a new recombinogenic act...

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Bibliographic Details
Main Authors: Jean-Marie Buerstedde, Noel Lowndes, David G Schatz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-07-01
Series:eLife
Subjects:
AID
homologous recombination
DNA repair
Online Access:https://elifesciences.org/articles/03110

Internet

https://elifesciences.org/articles/03110

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