Limited antibody specificity compromises epitranscriptomic analyses

Limited antibody specificity compromises epitranscriptomic analyses

A controversial discussion on the occurrence of the RNA modification m1A in mRNA takes a new turn, as an antibody with a central role in modification mapping was shown to also bind mRNA cap structures.

Bibliographic Details
Main Authors: Mark Helm, Frank Lyko, Yuri Motorin
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13684-3
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spelling doaj-b98f534df82c4c40aeb2c82e40ecf7d92021-05-11T12:03:37ZengNature Publishing GroupNature Communications2041-17232019-12-011011310.1038/s41467-019-13684-3Limited antibody specificity compromises epitranscriptomic analysesMark Helm0Frank Lyko1Yuri Motorin2Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University MainzDivision of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research CenterIMoPA, UMR7365 CNRS-University of Lorraine, BiopôleA controversial discussion on the occurrence of the RNA modification m1A in mRNA takes a new turn, as an antibody with a central role in modification mapping was shown to also bind mRNA cap structures.https://doi.org/10.1038/s41467-019-13684-3
collection DOAJ
language English
format Article
sources DOAJ
author Mark Helm
Frank Lyko
Yuri Motorin
spellingShingle Mark Helm
Frank Lyko
Yuri Motorin
Limited antibody specificity compromises epitranscriptomic analyses
Nature Communications
author_facet Mark Helm
Frank Lyko
Yuri Motorin
author_sort Mark Helm
title Limited antibody specificity compromises epitranscriptomic analyses
title_short Limited antibody specificity compromises epitranscriptomic analyses
title_full Limited antibody specificity compromises epitranscriptomic analyses
title_fullStr Limited antibody specificity compromises epitranscriptomic analyses
title_full_unstemmed Limited antibody specificity compromises epitranscriptomic analyses
title_sort limited antibody specificity compromises epitranscriptomic analyses
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-12-01
description A controversial discussion on the occurrence of the RNA modification m1A in mRNA takes a new turn, as an antibody with a central role in modification mapping was shown to also bind mRNA cap structures.
url https://doi.org/10.1038/s41467-019-13684-3
work_keys_str_mv AT markhelm limitedantibodyspecificitycompromisesepitranscriptomicanalyses
AT franklyko limitedantibodyspecificitycompromisesepitranscriptomicanalyses
AT yurimotorin limitedantibodyspecificitycompromisesepitranscriptomicanalyses
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