TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2

TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2

The transcription factor TCF7L1 is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in skin tumorigenesis has not yet been defined. Here we document TCF7L1 upregulation in skin squamous cell carcinoma (SCC) and demonstrate that TCF7L1 overex...

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Bibliographic Details
Main Authors: Amy T Ku, Timothy M Shaver, Ajay S Rao, Jeffrey M Howard, Christine N Rodriguez, Qi Miao, Gloria Garcia, Diep Le, Diane Yang, Malgorzata Borowiak, Daniel N Cohen, Vida Chitsazzadeh, Abdul H Diwan, Kenneth Y Tsai, Hoang Nguyen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
TCF7L1
skin squamous cell carcinoma
cell migration
oncogene-induced senescence
Online Access:https://elifesciences.org/articles/23242

Internet

https://elifesciences.org/articles/23242

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