Use of Precision-Cut Lung Slices as an Ex Vivo Tool for Evaluating Viruses and Viral Vectors for Gene and Oncolytic Therapy

Use of Precision-Cut Lung Slices as an Ex Vivo Tool for Evaluating Viruses and Viral Vectors for Gene and Oncolytic Therapy

Organotypic slice cultures recapitulate many features of an intact organ, including cellular architecture, microenvironment, and polarity, making them an ideal tool for the ex vivo study of viruses and viral vectors. Here, we describe a procedure for generating precision-cut ovine and murine tissue...

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Bibliographic Details
Main Authors: María C. Rosales Gerpe, Jacob P. van Vloten, Lisa A. Santry, Jondavid de Jong, Robert C. Mould, Adrian Pelin, John C. Bell, Byram W. Bridle, Sarah K. Wootton
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050118300743

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http://www.sciencedirect.com/science/article/pii/S2329050118300743

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