Cord blood-derived macrophage-lineage cells rapidly stimulate osteoblastic maturation in mesenchymal stem cells in a glycoprotein-130 dependent manner.

Cord blood-derived macrophage-lineage cells rapidly stimulate osteoblastic maturation in mesenchymal stem cells in a glycoprotein-130 dependent manner.

In bone, depletion of osteoclasts reduces bone formation in vivo, as does osteal macrophage depletion. How osteoclasts and macrophages promote the action of bone forming osteoblasts is, however, unclear. Since recruitment and differentiation of multi-potential stromal cells/mesenchymal stem cells (M...

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Bibliographic Details
Main Authors: Tania J Fernandes, Jason M Hodge, Preetinder P Singh, Damien G Eeles, Fiona M Collier, Ian Holten, Peter R Ebeling, Geoffrey C Nicholson, Julian M W Quinn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3772005?pdf=render

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http://europepmc.org/articles/PMC3772005?pdf=render

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