Targeting Jurkat T Lymphocyte Leukemia Cells by an Engineered Interferon-Alpha Hybrid Molecule

Targeting Jurkat T Lymphocyte Leukemia Cells by an Engineered Interferon-Alpha Hybrid Molecule

Background/Aims: Adult T-cell leukemia/lymphoma (ATL) is a very aggressive T cell malignancy that carries a poor prognosis, primarily due to its resistance to chemotherapy and to life-threatening infectious complications. Interferon-alpha (IFNα) has been used in combination with the anti-retroviral...

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Bibliographic Details
Main Authors: Dehai Yu, Zhonghua Du, Wei Li, Huaqiu Chen, Songgen Ye, Andrew R. Hoffman, Jiuwei Cui, Ji-Fan Hu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Jurkat-binding peptide
Phage display
Antitumor
Interferon-alpha
Synthetic interferon
Apoptosis
Cell proliferation
Online Access:http://www.karger.com/Article/FullText/477601

Internet

http://www.karger.com/Article/FullText/477601

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