The Mechanistic Differences in HLA-Associated Carbamazepine Hypersensitivity

The Mechanistic Differences in HLA-Associated Carbamazepine Hypersensitivity

Drug hypersensitivity reactions that resemble acute immune reactions are linked to certain human leucocyte antigen (HLA) alleles. Severe and life-threatening Stevens Johnson Syndrome and Toxic Epidermal Necrolysis following treatment with the antiepileptic and psychotropic drug Carbamazepine are ass...

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Bibliographic Details
Main Authors: Gwendolin S. Simper, Lareen S. Gräser, Alexander A. Celik, Joachim Kuhn, Heike Kunze-Schumacher, Gia-Gia T. Hò, Rainer Blasczyk, Andreas Pich, Christina Bade-Doeding
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Pharmaceutics
Subjects:
adverse drug reaction
hla-a*31:01
hla-b*15:02
carbamazepine
carbamazepine-10,11-epoxide
proteome
Online Access:https://www.mdpi.com/1999-4923/11/10/536

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https://www.mdpi.com/1999-4923/11/10/536

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