Deep Brain Stimulation of the Medial Septal Nucleus Induces Expression of a Virally Delivered Reporter Gene in Dentate Gyrus

Deep Brain Stimulation of the Medial Septal Nucleus Induces Expression of a Virally Delivered Reporter Gene in Dentate Gyrus

BackgroundMechanisms of deep brain stimulation (DBS) remain controversial, and spatiotemporal control of brain-wide circuits remains elusive. Adeno-associated viral (AAV) vectors have emerged as vehicles for spatiotemporal expression of exogenous transgenes in several tissues, including specific nuc...

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Bibliographic Details
Main Authors: Anton Fomenko, Darrin J. Lee, Chris McKinnon, Eun Jung Lee, Mitchell L. de Snoo, Elise Gondard, Clemens Neudorfer, Clement Hamani, Andres M. Lozano, Lorraine V. Kalia, Suneil K. Kalia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Neuroscience
Subjects:
neuromodulation
deep brain stimulation
viral vector
gene expression
medial septal nucleus
hippocampus
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00463/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00463/full

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