SV40 Transfected Human Anterior Cruciate Ligament Derived Ligamentocytes—Suitable as a Human in Vitro Model for Ligament Reconstruction?

SV40 Transfected Human Anterior Cruciate Ligament Derived Ligamentocytes—Suitable as a Human in Vitro Model for Ligament Reconstruction?

Cultured human primary cells have a limited lifespan undergoing dedifferentiation or senescence. Anterior cruciate ligaments (ACL) are hypocellular but tissue engineering (TE) requires high cell numbers. Simian virus (SV) 40 tumor (T) antigen expression could extend the lifespan of cells. This study...

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Bibliographic Details
Main Authors: Gundula Schulze-Tanzil, Philipp Arnold, Clemens Gögele, Judith Hahn, Annette Breier, Michael Meyer, Benjamin Kohl, Michaela Schröpfer, Silke Schwarz
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
anterior cruciate ligament
tissue engineering
pla
p(la-cl)
embroidered scaffold
ligamentocytes
sv40
Online Access:https://www.mdpi.com/1422-0067/21/2/593

Internet

https://www.mdpi.com/1422-0067/21/2/593

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