High Diagnostic Utility Incorporating a Targeted Neurodegeneration Gene Panel With MRI Brain Diagnostic Algorithms in Patients With Young-Onset Cognitive Impairment With Leukodystrophy

High Diagnostic Utility Incorporating a Targeted Neurodegeneration Gene Panel With MRI Brain Diagnostic Algorithms in Patients With Young-Onset Cognitive Impairment With Leukodystrophy

Leukodystrophies are a diverse group of genetic disorders that selectively involve the white matter of the brain and are a frequent cause of young-onset cognitive impairment. Genetic diagnosis is challenging. Data on the utility of incorporating brain magnetic resonance imaging (MRI) diagnostic algo...

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Bibliographic Details
Main Authors: Zhiyong Chen, Yi Jayne Tan, Michelle M. Lian, Moses Tandiono, Jia Nee Foo, Weng Khong Lim, Nagaendran Kandiah, Eng-King Tan, Adeline S. L. Ng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Neurology
Subjects:
NOTCH3
CADASIL
leukoencephalopathies
exome sequencing
cerebral small vessel disease
HtrA1 protein
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.631407/full

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https://www.frontiersin.org/articles/10.3389/fneur.2021.631407/full

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