Differential Effector Engagement by Oncogenic KRAS

Differential Effector Engagement by Oncogenic KRAS

Summary: KRAS can bind numerous effector proteins, which activate different downstream signaling events. The best known are RAF, phosphatidylinositide (PI)-3′ kinase, and RalGDS families, but many additional direct and indirect effectors have been reported. We have assessed how these effectors contr...

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Bibliographic Details
Main Authors: Tina L. Yuan, Arnaud Amzallag, Rachel Bagni, Ming Yi, Shervin Afghani, William Burgan, Nicole Fer, Leslie A. Strathern, Katie Powell, Brian Smith, Andrew M. Waters, David Drubin, Ty Thomson, Rosy Liao, Patricia Greninger, Giovanna T. Stein, Ellen Murchie, Eliane Cortez, Regina K. Egan, Lauren Procter, Matthew Bess, Kwong Tai Cheng, Chih-Shia Lee, Liam Changwoo Lee, Christof Fellmann, Robert Stephens, Ji Luo, Scott W. Lowe, Cyril H. Benes, Frank McCormick
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Subjects:
KRAS
RSK
RNAi screen
paralogs
redundancy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718300834

Internet

http://www.sciencedirect.com/science/article/pii/S2211124718300834

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