Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing

Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing

Shimpei Kubota et al. describe a pipeline for quantitative whole-organ analysis that that combines tissue clearing, 3D imaging, and machine learning for analysis of the tumour microenvironment. The authors apply this in a mouse model of lung tumour and reveal the role of TGF-β in remodelling the cel...

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Bibliographic Details
Main Authors: Shimpei I. Kubota, Kei Takahashi, Tomoyuki Mano, Katsuhiko Matsumoto, Takahiro Katsumata, Shoi Shi, Kazuki Tainaka, Hiroki R. Ueda, Shogo Ehata, Kohei Miyazono
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01786-y

Internet

https://doi.org/10.1038/s42003-021-01786-y

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