NAD⁺-carrying mesoporous silica nanoparticles can prevent oxidative stress-induced energy failures of both rodent astrocytes and PC12 cells.

NAD⁺-carrying mesoporous silica nanoparticles can prevent oxidative stress-induced energy failures of both rodent astrocytes and PC12 cells.

AIM: To test the hypothesis that NAD(+)-carrying mesoporous silica nanoparticles (M-MSNs@NAD+) can effectively deliver NAD(+) into cells to produce cytoprotective effects. METHODS & MATERIALS: NAD(+) was incorporated into M-MSNs. Primary rat astrocyte cultures and PC12 cells were treated with H₂...

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Bibliographic Details
Main Authors: Heyu Chen, Yao Wang, Jixi Zhang, Yingxin Ma, Caixia Wang, Ying Zhou, Hongchen Gu, Weihai Ying
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3767595?pdf=render

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http://europepmc.org/articles/PMC3767595?pdf=render

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