Guanabenz Downregulates Inflammatory Responses via eIF2α Dependent and Independent Signaling

Guanabenz Downregulates Inflammatory Responses via eIF2α Dependent and Independent Signaling

Integrated stress responses (ISR) may lead to cell death and tissue degeneration via eukaryotic translation initiation factor 2 α (eIF2α)-mediated signaling. Alleviating ISR by modulating eIF2α phosphorylation can reduce the symptoms associated with various diseases. Guanabenz is known to elevate th...

Full description

Bibliographic Details
Main Authors: Shinya Takigawa, Andy Chen, Akinobu Nishimura, Shengzhi Liu, Bai-Yan Li, Akihiro Sudo, Hiroki Yokota, Kazunori Hamamura
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:International Journal of Molecular Sciences
Subjects:
guanabenz
microarray
inflammation
Csf2 (GM-CSF)
eIF2α signaling
Online Access:http://www.mdpi.com/1422-0067/17/5/674

Internet

http://www.mdpi.com/1422-0067/17/5/674

Similar Items