SUMOylating Two Distinct Sites on the A-type Potassium Channel, Kv4.2, Increases Surface Expression and Decreases Current Amplitude

SUMOylating Two Distinct Sites on the A-type Potassium Channel, Kv4.2, Increases Surface Expression and Decreases Current Amplitude

Post-translational conjugation of Small Ubiquitin-like Modifier (SUMO) peptides to lysine (K) residues on target proteins alters their interactions. SUMOylation of a target protein can either promote its interaction with other proteins that possess SUMO binding domains, or it can prevent target prot...

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Bibliographic Details
Main Authors: Meghyn A. Welch, Lori A. Forster, Selin I. Atlas, Deborah J. Baro
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
SUMOylation
SUMO
Kv4
ion channel
trafficking
voltage-gated potassium channel
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00144/full

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https://www.frontiersin.org/article/10.3389/fnmol.2019.00144/full

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