Specific and sensitive hydrolysis probe-based real-time PCR detection of epidermal growth factor receptor variant III in oral squamous cell carcinoma.

Specific and sensitive hydrolysis probe-based real-time PCR detection of epidermal growth factor receptor variant III in oral squamous cell carcinoma.

BACKGROUND: The tumor-specific EGFR deletion mutant, EGFRvIII, is characterised by ligand-independent constitutive signalling. Tumors expressing EGFRvIII are resistant to current EGFR-targeted therapy. The frequency of EGFRvIII in head and neck squamous cell carcinoma (HNSCC) is disputed and may var...

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Bibliographic Details
Main Authors: John B McIntyre, Pinaki Bose, Alexander C Klimowicz, Nigel T Brockton, Stephanie Petrillo, Wayne Matthews, Jay Easaw, Anthony Magliocco, Joseph C Dort
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3280998?pdf=render

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http://europepmc.org/articles/PMC3280998?pdf=render

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