Inhibition of glutathione synthesis in brain endothelial cells lengthens S-phase transit time in the cell cycle: Implications for proliferation in recovery from oxidative stress and endothelial cell damage

Inhibition of glutathione synthesis in brain endothelial cells lengthens S-phase transit time in the cell cycle: Implications for proliferation in recovery from oxidative stress and endothelial cell damage

Oxidative stress-induced decrease in tissue or systemic glutathione (GSH) and damage to the vascular endothelium of the blood-brain barrier such as occurs in diabetes or stroke will have important implications for brain homeostasis. Endothelial proliferation or repair is crucial to preserving barri...

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Bibliographic Details
Main Authors: Carmina Buşu, Wei Li, Gloria Caldito, Tak Yee Aw
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Redox Biology
Subjects:
Nuclear-to-cytosolic GSH distribution
GSH and endothelial proliferation
GSH and cell cycle
DNA damage response
Brain microvascular endothelial cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231713000244

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http://www.sciencedirect.com/science/article/pii/S2213231713000244

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