Demonstration of an oligosaccharide-diphosphodolichol diphosphatase activity whose subcellular localization is different than those of dolichyl-phosphate-dependent enzymes of the dolichol cycle

Demonstration of an oligosaccharide-diphosphodolichol diphosphatase activity whose subcellular localization is different than those of dolichyl-phosphate-dependent enzymes of the dolichol cycle

Oligosaccharyl phosphates (OSPs) are hydrolyzed from oligosaccharide-diphosphodolichol (DLO) during protein N-glycosylation by an uncharacterized process. An OSP-generating activity has been reported in vitro, and here we asked if its biochemical characteristics are compatible with a role in endopla...

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Bibliographic Details
Main Authors: Ahmad Massarweh, Michaël Bosco, Soria Iatmanen-Harbi, Clarice Tessier, Nicolas Auberger, Patricia Busca, Isabelle Chantret, Christine Gravier-Pelletier, Stuart E.H. Moore
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Journal of Lipid Research
Subjects:
oligosaccharide-diphosphodolichol
endoplasmic reticulum
Golgi apparatus
isoprenoids
phosphatases
phospholipids/trafficking
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520351804

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http://www.sciencedirect.com/science/article/pii/S0022227520351804

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