A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells.

A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells.

Human cytomegalovirus (HCMV) is a widely distributed herpesvirus that causes significant morbidity in immunocompromised hosts. Inhibitors of viral DNA replication are available, but adverse effects limit their use. Alternative antiviral strategies may include inhibition of entry. We show that solubl...

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Bibliographic Details
Main Authors: Cora Stegmann, Daniel Hochdorfer, Diana Lieber, Narmadha Subramanian, Dagmar Stöhr, Kerstin Laib Sampaio, Christian Sinzger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5389858?pdf=render

Internet

http://europepmc.org/articles/PMC5389858?pdf=render

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