Loss of Caveolin-1 Is Associated with a Decrease in Beta Cell Death in Mice on a High Fat Diet

Loss of Caveolin-1 Is Associated with a Decrease in Beta Cell Death in Mice on a High Fat Diet

Elevated free fatty acids (FFAs) impair beta cell function and reduce beta cell mass as a consequence of the lipotoxicity that occurs in type 2 diabetes (T2D). We previously reported that the membrane protein caveolin-1 (CAV1) sensitizes to palmitate-induced apoptosis in the beta pancreatic cell lin...

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Bibliographic Details
Main Authors: Paloma Lillo Urzúa, Olinda Núñez Murillo, Mauricio Castro-Sepúlveda, María A. Torres-Quintana, Álvaro Lladser Caldera, Andrew F. G. Quest, Carolina Espinoza Robles, Paola Llanos Vidal, Sergio Wehinger
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
ERK activity
caveolin-1
high fat diet
insulin resistance
diabetes
Online Access:https://www.mdpi.com/1422-0067/21/15/5225

Internet

https://www.mdpi.com/1422-0067/21/15/5225

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