Lactate up-regulates the expression of lactate oxidation complex-related genes in left ventricular cardiac tissue of rats.

Lactate up-regulates the expression of lactate oxidation complex-related genes in left ventricular cardiac tissue of rats.

Besides its role as a fuel source in intermediary metabolism, lactate has been considered a signaling molecule modulating lactate-sensitive genes involved in the regulation of skeletal muscle metabolism. Even though the flux of lactate is significantly high in the heart, its role on regulation of ca...

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Main Authors: Daniele Gabriel-Costa, Telma Fatima da Cunha, Luiz Roberto Grassmann Bechara, Rodrigo Soares Fortunato, Luiz Henrique Marchesi Bozi, Marcele de Almeida Coelho, Maria Luiza Barreto-Chaves, Patricia Chakur Brum
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4440754?pdf=render

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http://europepmc.org/articles/PMC4440754?pdf=render

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