Transition from static culture to stirred tank bioreactor for the allogeneic production of therapeutic discogenic cell spheres

Transition from static culture to stirred tank bioreactor for the allogeneic production of therapeutic discogenic cell spheres

Abstract Background Culturing cells as cell spheres results in a tissue-like environment that drives unique cell phenotypes, making it useful for generating cell populations intended for therapeutic use. Unfortunately, common methods that utilize static suspension culture have limited scalability, m...

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Bibliographic Details
Main Authors: Daniel Rodriguez-Granrose, Jeff Zurawski, Will Heaton, Terry Tandeski, Galina Dulatov, Angelica Adrian Highsmith, Mason Conen, Garrett Clark, Amanda Jones, Hannah Loftus, Cameron LeBaron, Erin Scull, Niloo Farhang, Isaac Erickson, Justin Bingham, Paula Decaria, Nephi Jones, Kevin T. Foley, Lara Silverman
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Stem Cell Research & Therapy
Subjects:
Bioprocess
Progenitor cells
Cell spheres
Scale-up
Cell therapy
Stirred tank bioreactor (STR)
Online Access:https://doi.org/10.1186/s13287-021-02525-0

Internet

https://doi.org/10.1186/s13287-021-02525-0

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